(5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d₄-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine

Base Information

• Chemical Name: (5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d₄-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine
• CAS No.: 335441-01-5
• Molecular Formula: C₂₂H₂₆N₂O₂
• Molecular Weight: 354.429

Synonyms:(5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d₄-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine

Chemical Property of (5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d₄-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine

Chemical Property:

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Technology Process of (5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d₄-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine

There total 2 articles about (5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d₄-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Glyoxal (131543-46-9,107-22-2) + (1S,2R)-N,N'-Bis[(1-hydroxy-2-methyl-1-phenyl)ethyl]ethylene-d4-diamine (335441-00-4) → (5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d4-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine (335441-01-5)

Guidance literature:

In ethanol; for 12h; Heating;

DOI:10.1055/s-2001-10810

Reference yield:

N,N'-Bis-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-oxalamide (211555-92-9) → (5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d4-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine (335441-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / LiAlD₄ / tetrahydrofuran / 48 h / Heating

2: 70 percent / ethanol / 12 h / Heating

With lithium aluminium deuteride; In tetrahydrofuran; ethanol;

DOI:10.1055/s-2001-10810

Reference yield: 72.0%

(5S,5'S,4R,4'R,2R,2'R)-N,N'-Ethylene-d4-[(4,4'-dimethyl-5,5'-diphenyl)]-2,2'-bisoxazolidine (335441-01-5) → (2'S,1'R)-1,4-Bis-[(2'-hydroxy-1'-methyl-2'-phenyl)ethyl]-2,2,3,3-d4-piperazine

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Heating;

DOI:10.1055/s-2001-10810

upstream raw materials:

Glyoxal

(1S,2R)-N,N'-Bis[(1-hydroxy-2-methyl-1-phenyl)ethyl]ethylene-d₄-diamine

N,N'-Bis-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-oxalamide

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