Technology Process of (R)-dimethyl 2-(1-(4-(2-ethoxy-2-oxoethoxy)benzyl)-1H-indole-6-carboxamido) pentanedioate
There total 7 articles about (R)-dimethyl 2-(1-(4-(2-ethoxy-2-oxoethoxy)benzyl)-1H-indole-6-carboxamido) pentanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-(2-ethoxy-2-oxoethoxy)benzyl)-1H-indole-6-carboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dichloromethane;
for 0.25h;
D-glutamic acid dimethyl ester hydrochloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 5h;
DOI:10.1021/jm2002525
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
2.2: 18 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h
4.2: 5 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2002525
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
1.2: 18 h / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h
3.2: 5 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2002525
