2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Base Information

• Chemical Name: 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan
• CAS No.: 945771-78-8
• Molecular Formula: C₂₀H₁₇NO₇
• Molecular Weight: 383.357
• Mol file: 945771-78-8.mol

Synonyms:2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Chemical Property of 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

There total 7 articles about 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7-O-acyl-2-bromo-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-30-9) + sodium cyanide (143-33-9,25596-52-5) → 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (945771-78-8)

Guidance literature:

In dimethyl sulfoxide; at 55 ℃; for 1h;

DOI:10.1021/jo701656z

Reference yield: 65.0%

potassium cyanide + 7-O-acyl-2-bromo-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-30-9) → 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (945771-78-8)

Guidance literature:

at 55 - 100 ℃;

DOI:10.1021/jm200454y

Reference yield:

2-t-butyldimethylsilyl-7-isopropoxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-33-2) → 2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (945771-78-8)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane

2: pyridine

3: bromine / 1,2-dichloro-ethane

4: 55 - 100 °C

With pyridine; aluminum (III) chloride; bromine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm200454y

upstream raw materials:

7-O-acyl-2-bromo-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

sodium cyanide

2-t-butyldimethylsilyl-7-isopropoxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

C₂₅H₃₂O₇Si