(E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

Base Information

Chemical Name:(E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide
CAS No.:1448444-60-7
Molecular Formula:C₂₃H₂₂ClN₇O₂
Molecular Weight:463.926
Hs Code.:

Synonyms:(E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

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Chemical Property of (E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

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Technology Process of (E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

There total 6 articles about (E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.1%

: 1448444-59-4
6-amino-9-(3-aminophenyl)-7-(4-chlorophenyl)-7H-purin-8(9H)-one

: 1130155-48-4
(E)-4-(dimethylamino)-2-butenoic acid hydrochloride

: 1448444-60-7
(E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

Guidance literature:: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; acetonitrile; at 20 ℃; for 1h;

6-amino-9-(3-aminophenyl)-7-(4-chlorophenyl)-7H-purin-8(9H)-one; In dichloromethane; acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 1448444-50-5
tert-butyl 3-(6-amino-8-oxo-7H-purin-9(8H)-yl)phenylcarbamate

: 1448444-60-7
(E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxygen; copper diacetate; pyridine / N,N-dimethyl-formamide / 35 °C / Molecular sieve

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; acetonitrile / 1 h / 20 °C

3.2: 2 h / 20 °C

With pyridine; oxalyl dichloride; oxygen; copper diacetate; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1448444-49-2
tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenylcarbamate

: 1448444-60-7
(E)-N-(3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10 wt% Pd(OH)2 on carbon; hydrogenchloride; hydrogen / methanol / 60 °C

2.1: oxygen; copper diacetate; pyridine / N,N-dimethyl-formamide / 35 °C / Molecular sieve

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; acetonitrile / 1 h / 20 °C

4.2: 2 h / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; 10 wt% Pd(OH)2 on carbon; hydrogen; oxygen; copper diacetate; N,N-dimethyl-formamide; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;