4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 774133-54-9
• Molecular Formula: C₁₁H₁₇N₃O₂S
• Molecular Weight: 255.341

Synonyms:4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester

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Technology Process of 4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester

There total 1 articles about 4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester (774133-54-9) + 7,8-dihydro-5-hydroxy-2-(methylthio)-7-oxo-8-propylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (76360-85-5)

Guidance literature:

Reference yield:

4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester (774133-54-9) + 4-aminobenzamide (2835-68-9) → ethyl 2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxylate

Guidance literature:

4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 0.5h; Cooling with ice;

4-aminobenzamide; With [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 3h;

Reference yield:

4-propylamino-2-(methylsulfanyl)pyrimidine-5-carboxylic acid ethyl ester (774133-54-9) → (S)-tert-butyl (1-(((3-(2-(4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:

Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.5 h / 20 °C / Cooling with ice

1.2: 3 h / 110 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 7 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

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