5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Base Information

Chemical Name:5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide
CAS No.:1197331-55-7
Molecular Formula:C₃₀H₃₀Cl₂N₄O₃
Molecular Weight:565.499
Hs Code.:

Synonyms:5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

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Chemical Property of 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

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Technology Process of 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

There total 10 articles about 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197333-35-9
5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid

: 115619-01-7
4-(4-ethylpiperazin-1-yl)aniline

: 1197331-55-7
5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: With dmap; propylphosphonic anhydride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 5308-25-8
4-ethylpiperazine

: 1197331-55-7
5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 15 h / 80 °C

2: hydrogen / nickel / methanol / 7 h / 20 °C

3: dmap; propylphosphonic anhydride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With dmap; propylphosphonic anhydride; hydrogen; triethylamine; nickel; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 611-32-5
8-methylquinoline

: 1197331-55-7
5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; sulfuric acid / 18 h / 5 °C

2: potassium permanganate / pyridine; ethanol / 0.17 h / 110 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 1 h / 105 °C / Inert atmosphere

4: sulfuryl dichloride / acetonitrile / 0.25 h / 5 °C

5: dmap; propylphosphonic anhydride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With dmap; potassium permanganate; N-Bromosuccinimide; sulfuryl dichloride; sulfuric acid; propylphosphonic anhydride; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In pyridine; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;