N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

Base Information

Chemical Name:N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride
CAS No.:881678-78-0
Molecular Formula:C₁₈H₁₈N₂O₂S*ClH
Molecular Weight:362.88
Hs Code.:

Synonyms:N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

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Chemical Property of N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

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Technology Process of N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

There total 10 articles about N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 881673-86-5
tert-butyl methyl{[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}carbamate

: 881678-78-0
N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.04.014

Reference yield: 73.0%

: 881678-78-0
N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate; at 10 - 35 ℃; for 3h;

Reference yield:

: 881673-80-9
methyl 5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate

: 881678-78-0
N-methyl-1-[5-phenyl-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-methanamine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.17 h / -78 °C

1.2: 1.03 h / 20 °C

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 20 °C / Molecular sieve

3.1: methanol / 0.5 h / 20 °C

4.1: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

5.1: acetonitrile / 1.5 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 12 h / 105 °C / Inert atmosphere

7.1: hydrogenchloride / methanol; ethyl acetate / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; diisobutylaluminium hydride; sodium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; toluene; acetonitrile; 6.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2012.04.014