2,4,5,6,7-PENTABROMO-1H-BENZOIMIDAZOLE

Base Information

• Chemical Name: 2,4,5,6,7-PENTABROMO-1H-BENZOIMIDAZOLE
• CAS No.: 16865-25-1
• Molecular Formula: C7H Br5 N2
• Molecular Weight: 512.62
• Hs Code.: 2933990090
• Mol file: 16865-25-1.mol

Synonyms:Benzimidazole,2,4,5,6,7-pentabromo- (8CI); 2,4,5,6,7-Pentabromobenzimidazole

Chemical Property of 2,4,5,6,7-PENTABROMO-1H-BENZOIMIDAZOLE

Chemical Property:

• Vapor Pressure: 8.79E-12mmHg at 25°C
• Refractive Index: 1.797
• Boiling Point: 541.3°Cat760mmHg
• Flash Point: 281.2°C
• PSA: 28.68000
• Density: 2.912g/cm³
• LogP: 5.37540
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,4,5,6,7-Pentabromo-1H-benzo[d]imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,5,6,7-PENTABROMO-1H-BENZOIMIDAZOLE

There total 4 articles about 2,4,5,6,7-PENTABROMO-1H-BENZOIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-bromo-1H-1,3-benzodiazole (54624-57-6) → TBI (16865-25-1)

Guidance literature:

With bromine; In water; for 30h; Heating;

DOI:10.1016/S0968-0896(03)00403-6

Reference yield:

Benzimidazol-2-thiol (134469-07-1) → TBI (16865-25-1)

Guidance literature:

Benzimidazol-2-thiol; With hydrogen bromide; bromine; acetic acid; at 20 ℃; for 4h;

In water; for 24h; Reflux;

DOI:10.1039/c8ob02990c

Reference yield:

Benzimidazol-2-thiol (134469-07-1) → TBI (16865-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / hydrobromic acid; bromine / methanol / 1.75 h / 5 - 10 °C

2: 69 percent / bromine / H₂O / 30 h / Heating

With hydrogen bromide; bromine; In methanol; water;

DOI:10.1016/S0968-0896(03)00403-6

upstream raw materials:

2-bromo-1H-1,3-benzodiazole

Benzimidazol-2-thiol

Downstream raw materials:

2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole

4,5,6,7-tetrabromo-N-phenyl-1H-benzo[d]imidazol-2-amine

N₁-(4,5,6,7-tetrabromo-1H-benzo[d]imidazol-2-yl)benzene-1,4-diamine

Refernces

• 1、 Andrzejewska, Mariola,Pagano, Mario A.,Meggio, Flavio,Brunati, Anna Maria,Kazimierczuk, Zygmunt. "Polyhalogenobenzimidazoles: Synthesis and their inhibitory activity against casein kinases". . p. 3997 - 4002. Retrieved 2007/10/03.