5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Base Information

Chemical Name:5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride
CAS No.:1165876-06-1
Molecular Formula:C₂₀H₁₈N₄O₂*ClH
Molecular Weight:382.849
Hs Code.:

Synonyms:5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Suppliers and Price of 5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

There total 7 articles about 5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1165876-22-1
1,1-dimethylethyl 4-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,3-dihydro-2H-isoindole-2-carboxylate

: 1165876-06-1
5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jm5010336

Reference yield:

: 1159883-00-7
2,3-dihydro-1H-isoindole-4-carbonitrile

: 1165876-06-1
5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 5 h / 20 °C

2: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol / 6.5 h / 50 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 80 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm5010336

Reference yield:

: 1165876-20-9
1,1-dimethylethyl 4-cyano-1,3-dihydro-2H-isoindole-2-carboxylate

: 1165876-06-1
5-[3-(2,3-dihydro-1H-isoindol-4-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol / 6.5 h / 50 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm5010336