(R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

Base Information

Chemical Name:(R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol
CAS No.:1613638-93-9
Molecular Formula:C₂₁H₂₀N₄O₃S
Molecular Weight:408.481
Hs Code.:

Synonyms:(R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

Chemical Property:

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Technology Process of (R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

There total 7 articles about (R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613638-92-8
(R)-2-[5-(3-methylsulfanyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

: 1613638-93-9
(R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

Guidance literature:: With Oxone; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1613638-93-9
(R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

3: Oxone / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With Oxone; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; L-proline; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613638-93-9
(R)-2-[5-(3-methanesulfonyl-1H-indazol-5-yl)pyridin-3-ylamino]-2-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

3: Oxone / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With Oxone; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; L-proline; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;