2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
CAS No.:1425052-38-5
Molecular Formula:C₁₆H₁₆F₇NO
Molecular Weight:371.298
Hs Code.:

Synonyms:2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Chemical Property:

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Technology Process of 2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

There total 3 articles about 2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6051-13-4
2-cyclohexylpropanoic acid

: 651-83-2
4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

: 1425052-38-5
2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With oxalyl dichloride; In toluene; at 0 - 20 ℃; for 12.5h; Reflux; Inert atmosphere;
DOI:10.1021/ja400648w

Reference yield:

: 116505-07-8
2-cyclohexylpropanoyl chloride

: 651-83-2
4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

: 1425052-38-5
2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: In toluene; Reflux;
DOI:10.1021/ja508165a

Reference yield:

: 6051-13-4
2-cyclohexylpropanoic acid

: 1425052-38-5
2-cyclohexyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 0 - 20 °C

2: toluene / Reflux

With oxalyl dichloride; In dichloromethane; toluene;
DOI:10.1021/ja508165a