5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

Base Information

Chemical Name:5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol
CAS No.:1350900-68-3
Molecular Formula:C₁₉H₂₁FN₂O₃
Molecular Weight:344.386
Hs Code.:

Synonyms:5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

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Chemical Property of 5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

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Technology Process of 5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

There total 3 articles about 5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 103438-85-3
4-fluoro-3-hydroxybenzaldehyde

: 148245-18-5
1-(2,3-dihydro-1,4-benzodioxin-6-yl)piperazine

: 1350900-68-3
5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 60 ℃;
DOI:10.1002/jlcr.3074

Reference yield: 66.0%

: 1-(1,4-benzodioxine-6-yl)piperazine

: 103438-85-3
4-fluoro-3-hydroxybenzaldehyde

: 1350900-68-3
5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 60 ℃; for 24h;
DOI:10.1021/jm200762g

Reference yield:

: 22013-33-8
6-amino-3,4-benzodioxane

: 1350900-68-3
5-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)piperazin-1-yl)-methyl)-2-fluorophenol

Guidance literature:: Multi-step reaction with 2 steps

1: ethylene glycol / 150 °C / Inert atmosphere

2: acetic acid; sodium cyanoborohydride / methanol / 60 °C

With sodium cyanoborohydride; acetic acid; In methanol; ethylene glycol;
DOI:10.1002/jlcr.3074