5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Base Information

Chemical Name:5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran
CAS No.:138854-57-6
Molecular Formula:C₂₁H₂₅BrO₃
Molecular Weight:405.332
Hs Code.:

Synonyms:5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Suppliers and Price of 5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

There total 7 articles about 5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 138854-56-5
5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-6-(3-hydroxypropyl)-2-methoxybenzofuran

: 138854-57-6
5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 0.75h;
DOI:10.1021/jm00085a019

Reference yield:

: 100-44-7
benzyl chloride

: 138854-57-6
5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / butan-2-one / 22 h / Heating

2: 1.) BH₃*THF, 2.) a) 30percent aq. H₂O₂, 1 N aq. NaOH, b) NaS / 1.) 0 deg C, 75 min, 2.) a) THF, methanol, 30 min, b) H₂O

3: 68 percent / CBr₄, (C₆H₅)3P / CH₂Cl₂ / 0.75 h

With sodium hydroxide; borane-THF; carbon tetrabromide; dihydrogen peroxide; potassium carbonate; triphenylphosphine; In dichloromethane; butanone;
DOI:10.1021/jm00085a019

Reference yield:

: 13380-24-0
2,3-dihydro-3,3-dimethyl-2-methoxy-5-benzofuranol

: 138854-57-6
5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-3,3-dimethyl-2-methoxybenzofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / K₂CO₃ / butan-2-one / 4 h / Heating

2: 75 percent / 1,2-dichloro-benzene / 18 h / Heating

3: 90 percent / K₂CO₃ / butan-2-one / 22 h / Heating

4: 1.) BH₃*THF, 2.) a) 30percent aq. H₂O₂, 1 N aq. NaOH, b) NaS / 1.) 0 deg C, 75 min, 2.) a) THF, methanol, 30 min, b) H₂O

5: 68 percent / CBr₄, (C₆H₅)3P / CH₂Cl₂ / 0.75 h

With sodium hydroxide; borane-THF; carbon tetrabromide; dihydrogen peroxide; potassium carbonate; triphenylphosphine; In dichloromethane; 1,2-dichloro-benzene; butanone;
DOI:10.1021/jm00085a019