Technology Process of 4-(furan-2-yl)-3-(toluene-4-sulfonyloxmethyl)butyric acid tert-butyl ester
There total 6 articles about 4-(furan-2-yl)-3-(toluene-4-sulfonyloxmethyl)butyric acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 100 percent / NaH / tetrahydrofuran / 0 °C
2.1: 97 percent / H2 / Wilkinson's catalyst / tetrahydrofuran / 45 °C / 2585.74 Torr
3.1: LDA / tetrahydrofuran / -78 °C
3.2: tetrahydrofuran
4.1: 90 percent / aq LiOH / tetrahydrofuran; propan-2-ol
5.1: BH3*SMe2 / tetrahydrofuran / 0 °C
6.1: 90 percent / TEA / CH2Cl2 / 0 °C
With
lithium hydroxide; dimethylsulfide borane complex; TEA; hydrogen; sodium hydride; lithium diisopropyl amide;
Wilkinson's catalyst;
In
tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.06.090
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 97 percent / H2 / Wilkinson's catalyst / tetrahydrofuran / 45 °C / 2585.74 Torr
2.1: LDA / tetrahydrofuran / -78 °C
2.2: tetrahydrofuran
3.1: 90 percent / aq LiOH / tetrahydrofuran; propan-2-ol
4.1: BH3*SMe2 / tetrahydrofuran / 0 °C
5.1: 90 percent / TEA / CH2Cl2 / 0 °C
With
lithium hydroxide; dimethylsulfide borane complex; TEA; hydrogen; lithium diisopropyl amide;
Wilkinson's catalyst;
In
tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.06.090
