(4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester
CAS No.:329969-56-4
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:(4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

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Chemical Property of (4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

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Technology Process of (4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

There total 1 articles about (4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5153-67-3
nitrostyrene

: N-(t-Butoxycarbonyl)-N-(4-methoxyphenyl)-(E)-2-buten-1-amine

: (4-methoxy-phenyl)-(3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

: (4-Methoxy-phenyl)-((Z)-(3R,4S)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

: 329969-56-4
(4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

Guidance literature:: N-(t-Butoxycarbonyl)-N-(4-methoxyphenyl)-(E)-2-buten-1-amine; With n-butyllithium; (-)-sparteine; In hexane; toluene; at -78 ℃;

nitrostyrene; In hexane; toluene; at -78 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja0271375

Reference yield:

: 329969-56-4
(4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

: 3-allyl-1,3-dimethyl-4-phenyl-pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: dimethyl sulfide / CH₂Cl₂ / -78 - 20 °C

2.1: 2-methyl-2-butene; aq. NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol

3.1: HCl; aq. AcOH / diethyl ether

4.1: H₂ / Raney Ni / methanol / 12929 Torr

5.1: 90 percent / DMAP; triethylamine / CH₂Cl₂ / 20 °C

6.1: LDA / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran / -78 - 20 °C

6.3: LAH / tetrahydrofuran / 6 h / Heating

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; ozone; acetic acid; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja0271375

Reference yield:

: 329969-56-4
(4-Methoxy-phenyl)-((Z)-(3S,4R)-3-methyl-5-nitro-4-phenyl-pent-1-enyl)-carbamic acid tert-butyl ester

: 3-allyl-1,3-dimethyl-4-phenyl-pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: dimethyl sulfide / CH₂Cl₂ / -78 - 20 °C

2.1: 2-methyl-2-butene; aq. NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol

3.1: HCl; aq. AcOH / diethyl ether

4.1: H₂ / Raney Ni / methanol / 12929 Torr

5.1: 90 percent / DMAP; triethylamine / CH₂Cl₂ / 20 °C

6.1: LDA / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran / -78 - 20 °C

6.3: LAH / tetrahydrofuran / 6 h / Heating

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; ozone; acetic acid; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja0271375