4H-1,2,4-Triazole,3,4-dimethyl-(8CI,9CI)

Base Information

• Chemical Name: 4H-1,2,4-Triazole,3,4-dimethyl-(8CI,9CI)
• CAS No.: 16778-74-8
• Molecular Formula: C4H7 N3
• Molecular Weight: 97.1197
• Mol file: 16778-74-8.mol

Synonyms:3,4-Dimethyl-4H-1,2,4-triazole

Chemical Property of 4H-1,2,4-Triazole,3,4-dimethyl-(8CI,9CI)

Chemical Property:

• Melting Point: 97.5-98 °C
• Boiling Point: 205.9±23.0 °C(Predicted)
• PKA: 3.50±0.10(Predicted)
• PSA: 30.71000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 0.12350

Purity/Quality:

3,4-DIMETHYL-4H-1,2,4-TRIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1,2,4-Triazole,3,4-dimethyl-(8CI,9CI)

There total 3 articles about 4H-1,2,4-Triazole,3,4-dimethyl-(8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,2-dimethyl-5-mercapto-1,3,4-triazole (38942-50-6) → 3,4-dimethyl-4H-1,2,4-triazole (16778-74-8)

Guidance literature:

With dihydrogen peroxide; acetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1055/s-2005-921754

Reference yield: 73.0%

4,5-dimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, (38942-50-6) → 3,4-dimethyl-4H-1,2,4-triazole (16778-74-8)

Guidance literature:

4,5-dimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione,; With dihydrogen peroxide; acetic acid; In dichloromethane; water; at 0 - 20 ℃;

With sodium hydroxide; In water; pH=12;

Reference yield:

→ 3,4-dimethyl-4H-1,2,4-triazole (16778-74-8)

Guidance literature:

aus 3,4-Dimethyltriazolon-5 und LiAlH4 in THF;

upstream raw materials:

1,2-dimethyl-5-mercapto-1,3,4-triazole

4,5-dimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione,

Refernces

• 1、 -. "DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)". Page/Page column 81. . Retrieved 2010/03/02.