2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

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Chemical Name:2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester
CAS No.:158585-03-6
Molecular Formula:C₅₂H₄₉BrO₆Si
Molecular Weight:877.947
Hs Code.:

Synonyms:2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

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Chemical Property of 2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

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Technology Process of 2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

There total 10 articles about 2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 158585-00-3
2-bromo-3-benzyloxy-benzyl alcohol

: 158585-02-5
2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid

: 158585-03-6
2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 25 ℃; for 0.666667h;
DOI:10.1021/ja00097a072

Reference yield:

: 16534-12-6
3,5-dihydroxy-4-bromobenzoic acid

: 158585-03-6
2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃ / dimethylformamide / 4 h / 25 °C

2: 100 percent / DIBALH / CH₂Cl₂; toluene / 1 h / 0 °C

3: 82 percent / imidazole / dimethylformamide / 1 h / 25 °C

4: 60 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 to 25 deg C, 30 min

5: 93 percent / Ph₃P, DEAD / tetrahydrofuran / 0.67 h / 25 °C

With 1H-imidazole; n-butyllithium; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1700-37-4
3-Benzyloxybenzaldehyde

: 158585-03-6
2,6-Bis-benzyloxy-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid 3-benzyloxy-2-bromo-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeNHCH₂CH₂NMe₂, n-BuLi, PhLi, 2.) 1,2-dibromotetrafluoroethane / 1.) benzene, pentane, cyclohexane, Et₂O, 25 deg C, 30 min; 25 deg C, 30 min; 25 deg C, 7 h, 2.) THF, -78 to 25 deg C, 30 min

2: 96 percent / DIBALH / CH₂Cl₂ / 1 h / 0 °C

3: 93 percent / Ph₃P, DEAD / tetrahydrofuran / 0.67 h / 25 °C

With n-butyllithium; 1,2-dibromo-1,1,2,2-tetrafluoroethane; diisobutylaluminium hydride; N,N',N'-trimethylenediamine; phenyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;