2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

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Chemical Name:2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide
CAS No.:167980-80-5
Molecular Formula:C₄₂H₅₈N₆O₆
Molecular Weight:742.959
Hs Code.:

Synonyms:2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

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Chemical Property of 2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

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Technology Process of 2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

There total 6 articles about 2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106719-44-2
Boc-D-Lys-OH

: 167980-80-5
2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / 1 N aq. NaOH / 15 h

2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et₂O, RT, 24 h

3: DMAP, triethylamine / CH₂Cl₂ / 2.25 h / Ambient temperature

4: sodium azide / dimethylformamide / 1.5 h / 80 °C

5: 95 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr

6: 1-hydroxybenzotriazole, EDC / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022

Reference yield:

: 614-68-6
2-tolyl isocyanate

: 167980-80-5
2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / 1 N aq. NaOH / 15 h

2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et₂O, RT, 24 h

3: DMAP, triethylamine / CH₂Cl₂ / 2.25 h / Ambient temperature

4: sodium azide / dimethylformamide / 1.5 h / 80 °C

5: 95 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr

6: 1-hydroxybenzotriazole, EDC / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022

Reference yield:

: 167980-57-6
methanesulfonic acid 2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl ester

: 167980-80-5
2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(R)-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / dimethylformamide / 1.5 h / 80 °C

2: 95 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr

3: 1-hydroxybenzotriazole, EDC / CH₂Cl₂ / 24 h / Ambient temperature

With sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022