Phenol, 4-amino-2-(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Phenol, 4-amino-2-(1-methylethyl)- (9CI)
• CAS No.: 16750-66-6
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Mol file: 16750-66-6.mol

Synonyms:Phenol,4-amino-2-isopropyl- (6CI,7CI,8CI); 2-Isopropyl-4-aminophenol;4-Amino-2-isopropylphenol

Chemical Property of Phenol, 4-amino-2-(1-methylethyl)- (9CI)

Chemical Property:

• PSA: 46.25000
• LogP: 2.67900

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-isopropylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-2-isopropylphenol is a building block used in the preparation of benzoate and benzamide derivatives as FXR antagonists.

Technology Process of Phenol, 4-amino-2-(1-methylethyl)- (9CI)

There total 9 articles about Phenol, 4-amino-2-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-isopropyl-[1,4]benzoquinone 4-oxime (107244-57-5) → 2-iso-Propyl-4-aminophenol (16750-66-6)

Guidance literature:

With hydrogen; Ra/Ni; In methanol; for 5h; under 2585.81 Torr;

Reference yield: 74.8%

1-(benzyloxy)-4-nitro-2-(prop-1-en-2-yl)benzene → 2-iso-Propyl-4-aminophenol (16750-66-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 30 ℃; for 3h; under 2585.81 Torr;

Reference yield:

2-bromo-4-nitrophenol (5847-59-6) → 2-iso-Propyl-4-aminophenol (16750-66-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / 80 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 25 - 90 °C / Inert atmosphere

3: hydrogen; palladium on activated charcoal / ethyl acetate / 3 h / 30 °C / 2585.81 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; potassium carbonate; In 1,4-dioxane; water; ethyl acetate; acetonitrile;

upstream raw materials:

2-(1-methylethyl)phenol

4-sulfobenzenediazonium

2-isopropyl-[1,4]benzoquinone 4-oxime

1-(benzyloxy)-2-bromo-4-nitrobenzene

Downstream raw materials:

N-(4-Hydroxy-3-isopropyl-phenyl)-acetamide

2-iso-Propyl-4-tosylaminophenol

2-iso-Propyl-4-tosylimino-1,4-benzoquinone

2-iso-Propyl-4-tosylimino-6-chloro-1,4-benzoquinone