2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

Base Information

Chemical Name:2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester
CAS No.:391859-16-8
Molecular Formula:C₃₇H₃₄O₇S
Molecular Weight:622.739
Hs Code.:

Synonyms:2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

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Chemical Property of 2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

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Technology Process of 2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

There total 8 articles about 2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 317350-40-6
2-Benzyloxy-4,5-dimethoxybenzoyl chloride

: 391859-15-7
1-[(R)-1-(1-Hydroxy-3-phenylsulfanyl-prop-2-ynyl)-7-methoxy-indan-1-yl]-ethanone

: 391859-16-8
2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

Guidance literature:: With dmap; In dichloromethane;
DOI:10.1021/ol016696y

Reference yield:

: 302336-24-9
(R)-(1-hydroxymethyl-7-methoxyindan-1-yl)methyl 2-furoate

: 391859-16-8
2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / dimethylformamide

2.1: K₂CO₃ / methanol

3.1: Dess-Martin periodinane / acetonitrile

3.2: 88 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

4.1: 99 percent / BF₃*Et₂O / CH₂Cl₂

5.1: 80 percent / HMPA / tetrahydrofuran

6.1: 96 percent / Dess-Martin periodinane / acetonitrile

7.1: 53 percent / HMPA / tetrahydrofuran / -78 °C

8.1: 96 percent / DMAP / CH₂Cl₂

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; boron trifluoride diethyl etherate; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3.1: Dess-Martin oxidation / 6.1: Dess-Martin oxidation;
DOI:10.1021/ol016696y

Reference yield:

: 391859-13-5
(R)-1-Acetyl-7-methoxy-indan-1-carbaldehyde

: 391859-16-8
2-Benzyloxy-4,5-dimethoxy-benzoic acid 1-((R)-1-acetyl-7-methoxy-indan-1-yl)-3-phenylsulfanyl-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / HMPA / tetrahydrofuran / -78 °C

2: 96 percent / DMAP / CH₂Cl₂

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol016696y