3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

Base Information

Chemical Name:3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride
CAS No.:74547-09-4
Molecular Formula:C₁₄H₁₂FN₅O₄S
Molecular Weight:365.345
Hs Code.:

Synonyms:3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

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Chemical Property of 3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

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Technology Process of 3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

There total 5 articles about 3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 454-93-3
3-fluorosulfonyl-benzoyl chloride

: 74539-02-9
1-(2-aminoethyl)hypoxanthine

: 74547-09-4
3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 1h;
DOI:10.1021/jm00184a015

Reference yield:

: 74539-00-7
1-(2-chloroethyl)hypoxanthine

: 74547-09-4
3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / NaN₃ / dimethylformamide / 3 h / 100 °C

2: 98 percent / H₂ / PtO₂ / ethanol; H₂O / 24 h / 760 Torr / Ambient temperature

3: 84 percent / (i-Pr₂)2NEt / dimethylformamide / 1 h / 20 - 25 °C

With sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00184a015

Reference yield:

: 74538-99-1
6-(2-hydroxyethoxy)purine

: 74547-09-4
3-[2-(6-Oxo-6,9-dihydro-purin-1-yl)-ethylcarbamoyl]-benzenesulfonyl fluoride

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / SOCl₂ / CH₂Cl₂ / 1.) from 0 to 25 deg C, 1 h, 2.) reflux, 2.5 h

2: 65 percent / NaN₃ / dimethylformamide / 3 h / 100 °C

3: 98 percent / H₂ / PtO₂ / ethanol; H₂O / 24 h / 760 Torr / Ambient temperature

4: 84 percent / (i-Pr₂)2NEt / dimethylformamide / 1 h / 20 - 25 °C

With thionyl chloride; sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00184a015