7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

Base Information

Chemical Name:7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one
CAS No.:1418025-27-0
Molecular Formula:C₂₅H₂₄ClN₅O
Molecular Weight:445.951
Hs Code.:

Synonyms:7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

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Chemical Property of 7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

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Technology Process of 7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

There total 9 articles about 7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 110-89-4
piperidine

: 1193-21-1
4,6-dichloropyrimidine

: 1418025-85-0
3-aminomethyl-7-chloro-1-phenyl-1H-quinolin-4-one

: 1418025-27-0
7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

Guidance literature:: 4,6-dichloropyrimidine; 3-aminomethyl-7-chloro-1-phenyl-1H-quinolin-4-one; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 1.5h; under 760.051 Torr; Inert atmosphere; Sealed tube; Microwave irradiation;

piperidine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 2h; under 760.051 Torr; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418025-27-0
7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

5.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 120 °C / 760.05 Torr / Inert atmosphere; Sealed tube; Microwave irradiation

6.2: 2 h / 120 °C / 760.05 Torr / Inert atmosphere; Sealed tube; Microwave irradiation

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418025-27-0
7-chloro-1-phenyl-3-[(6-piperidin-1-yl-pyrimidin-4-ylamino)methyl]-1H-quinolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

1.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 120 °C / 760.05 Torr / Inert atmosphere; Sealed tube; Microwave irradiation

5.2: 2 h / 120 °C / 760.05 Torr / Inert atmosphere; Sealed tube; Microwave irradiation

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;