2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

Base Information

Chemical Name:2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide
CAS No.:118698-09-2
Molecular Formula:C₁₆H₁₅ClN₄O₂
Molecular Weight:330.774
Hs Code.:

Synonyms:2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

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Chemical Property of 2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

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Technology Process of 2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

There total 7 articles about 2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 118695-99-1
2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide

: 118698-09-2
2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

Guidance literature:: With acetic acid; 3-chloro-benzenecarboperoxoic acid; at 60 ℃; for 4h;
DOI:10.1021/jm00114a007

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 118698-09-2
2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Et₃N / ethanol / 1.75 h / Heating

2: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

3: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

4: 48 percent / 0.13 h / 210 - 220 °C

5: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: 1.) 1,1'-carbonyldiimidazole / 1.) THF, RT, 3 h, 2.) THF, RT, overnight

7: 88 percent / m-chloroperbenzoic acid, AcOH / 4 h / 60 °C

With sodium hydroxide; hydrogen; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007

Reference yield:

: 90559-63-0
N-(3-nitro-2-pyridinyl)glycine ethyl ester

: 118698-09-2
2-(4-chlorophenyl)-N,N-dimethyl-3H-imidazo<4,5-b>pyridine-3-acetamide 4-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

2: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

3: 48 percent / 0.13 h / 210 - 220 °C

4: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

5: 1.) 1,1'-carbonyldiimidazole / 1.) THF, RT, 3 h, 2.) THF, RT, overnight

6: 88 percent / m-chloroperbenzoic acid, AcOH / 4 h / 60 °C

With sodium hydroxide; hydrogen; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007