(4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

Base Information

Chemical Name:(4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol
CAS No.:345319-60-0
Molecular Formula:C₃₄H₄₆O₃Si
Molecular Weight:530.823
Hs Code.:

Synonyms:(4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

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Chemical Property of (4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

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Technology Process of (4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

There total 10 articles about (4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {1-[5-benzyloxy-2-(4-methoxy-benzyloxy)-pentyl]-2-methyl-pent-4-enyloxy}-tert-butyl-diphenyl-silane

: (4S,6R,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

: 345319-60-0
(4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4039(01)00278-7

Reference yield:

: 83458-93-9
(3S)-6-(Benzyloxy)hexane-1,3-diol

: 345319-60-0
(4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: TMSCl / methanol; tetrahydrofuran / 16 h / 20 °C

2.1: DIBAL-H / CH₂Cl₂ / 1 h / 0 °C

3.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

4.1: toluene / 8 h / -78 °C

5.1: imidazole / dimethylformamide / 16 h / 100 °C

6.1: 9-BBN / tetrahydrofuran / 0.5 h / 20 °C

6.2: NaBO₃ / 16 h / 20 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

8.1: tetrahydrofuran / 1 h / -78 - 20 °C

9.1: DDQ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; chloro-trimethyl-silane; diisobutylaluminium hydride; Dess-Martin periodane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: Dess-Martin oxidation / 7.1: Dess-Martin oxidation;
DOI:10.1016/S0040-4039(01)00278-7

Reference yield:

: 83458-92-8
((2S,3S)-3-(3-(benzyloxy)propyl)oxiran-2-yl)methanol

: 345319-60-0
(4S,6S,7R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-7-methyl-dec-9-en-4-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaAl(OMe)3H / tetrahydrofuran / 0 - 20 °C

2.1: TMSCl / methanol; tetrahydrofuran / 16 h / 20 °C

3.1: DIBAL-H / CH₂Cl₂ / 1 h / 0 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

5.1: toluene / 8 h / -78 °C

6.1: imidazole / dimethylformamide / 16 h / 100 °C

7.1: 9-BBN / tetrahydrofuran / 0.5 h / 20 °C

7.2: NaBO₃ / 16 h / 20 °C

8.1: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

9.1: tetrahydrofuran / 1 h / -78 - 20 °C

10.1: DDQ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; chloro-trimethyl-silane; NaAl(OMe)3H; diisobutylaluminium hydride; Dess-Martin periodane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: Dess-Martin oxidation / 8.1: Dess-Martin oxidation;
DOI:10.1016/S0040-4039(01)00278-7