(-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Base Information

Chemical Name:(-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester
CAS No.:1415125-79-9
Molecular Formula:C₃₆H₂₈N₂O₇S
Molecular Weight:632.694
Hs Code.:

Synonyms:(-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Suppliers and Price of (-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

There total 4 articles about (-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1415125-81-3
N-but-2-ynyl-2-nitro-N-(2-oxoethyl)benzenesulfonamide

: 2-(ethynyloxy)-naphthalene

: 1415125-79-9
(-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In dichloromethane; at 80 ℃; for 16h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/ol3027158

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1415125-79-9
(-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

3: hydrogenchloride / water; tetrahydrofuran / 4 h / Reflux; Inert atmosphere

4: (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen / dichloromethane / 16 h / 80 °C / Inert atmosphere; Schlenk technique

With hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; potassium carbonate; triethylamine; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol3027158

Reference yield:

: 1415125-90-4
C₁₄H₁₈N₂O₆S

: 1415125-79-9
(-)-4-methyl-6-(naphthalen-2-yloxy)-2-(2-nitrobenzenesulfonyl)-2,3,5,7a-tetrahydro-1H-isoindole-5-carboxylic acid naphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; tetrahydrofuran / 4 h / Reflux; Inert atmosphere

2: (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen / dichloromethane / 16 h / 80 °C / Inert atmosphere; Schlenk technique

With hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol3027158