N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

Base Information

Chemical Name:N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide
CAS No.:1431531-07-5
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

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Chemical Property of N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

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Technology Process of N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

There total 4 articles about N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431532-82-9
tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)carbamate

: 108-24-7
acetic anhydride

: 1431531-07-5
N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

Guidance literature:: tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)carbamate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.333333h;

acetic anhydride; With pyridine; at 20 ℃; for 0.25h;

Reference yield:

: 1431532-81-8
tert-butyl ((2S)-1-(3-((4-(cyclopropylmethoxy)benzoyl)amino)-4-nitrophenoxy)propan-2-yl)carbamate

: 1431531-07-5
N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; water / 0.5 h / 20 °C

1.2: 1 h / 80 °C

2.1: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

2.2: 0.25 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 2369-11-1
5-fluoro-2-nitroaniline

: 1431531-07-5
N-((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

2.2: 0.17 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; water / 0.5 h / 20 °C

3.2: 1 h / 80 °C

4.1: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

4.2: 0.25 h / 20 °C

With hydrogenchloride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;