(S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide

Base Information

• Chemical Name: (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide
• CAS No.: 942615-15-8
• Molecular Formula: C₂₈H₂₉F₂N₃O₆
• Molecular Weight: 541.552

Synonyms:(S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide

Chemical Property of (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide

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Technology Process of (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide

There total 1 articles about (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-bromoisobutyrate (600-00-0) + (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(3,5-difluoro-4-hydroxyphenyl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide (942615-12-5) → (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide (942615-15-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 1h;

Reference yield:

(S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-ethoxycarbonyl-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide (942615-15-8) → (S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-carboxy-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide (942615-16-9)

Guidance literature:

With sodium hydroxide; ethanol; water; at 20 ℃;

upstream raw materials:

ethyl 2-bromoisobutyrate

(S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-(3,5-difluoro-4-hydroxyphenyl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide

Downstream raw materials:

(S)-4-(5-picolin-2-yl)-3-hydroxymethyl-N-[3,5-difluoro-4-(1-carboxy-1-methyl)ethyloxyphenyl]-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide

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