6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

Base Information

Chemical Name:6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone
CAS No.:1401207-51-9
Molecular Formula:C₂₄H₂₅NO₅S₂
Molecular Weight:471.598
Hs Code.:

Synonyms:6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

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Chemical Property of 6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

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Technology Process of 6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

There total 1 articles about 6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 597556-90-6
6-(but-3-enyl)-4-(phenylthio)-1-(4-toluenesulfonyl)-1,2,5,6-tetrahydropyridin-2-one

: 1401207-51-9
6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; p-cresol; In toluene; at 150 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.tetlet.2012.08.031

Reference yield: 77.0%

: 1401207-51-9
6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

: 1401207-56-4
6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Reflux;
DOI:10.1016/j.tetlet.2012.08.031

Reference yield:

: 1401207-51-9
6-(E)-[4-(methoxycarbonyl)but-3-enyl]-4-(phenylthio)-1-tosyl-1,2,5,6-tetrahydro-2-pyridinone

: C₁₇H₁₉NO₃S

: C₁₇H₁₉NO₃S

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Reflux

2: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; toluene; mineral oil; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2012.08.031