4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1440175-03-0
Molecular Formula:C₃₃H₃₄ClIN₄O₆
Molecular Weight:745.014
Hs Code.:

Synonyms:4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Suppliers and Price of 4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

There total 4 articles about 4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride

: 1440175-00-7
4-chloro-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

: 1440175-03-0
4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: 4-chloro-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In acetonitrile; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride; In acetonitrile; mineral oil; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/ejoc.201300261

Reference yield:

: 1440174-97-9
4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1440175-03-0
4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodo-succinimide / dichloromethane / 0.5 h / 40 °C / Inert atmosphere

2.1: sodium hydride / acetonitrile; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; In dichloromethane; acetonitrile; mineral oil;
DOI:10.1002/ejoc.201300261

Reference yield:

: 62981-82-2
2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidine

: 1440175-03-0
4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodo-6-methyl-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 4 h / Reflux; Inert atmosphere

2.1: pyridine / 3.5 h / 20 °C / Inert atmosphere

3.1: N-iodo-succinimide / dichloromethane / 0.5 h / 40 °C / Inert atmosphere

4.1: sodium hydride / acetonitrile; mineral oil / 0.25 h / 0 °C / Inert atmosphere

4.2: 1.5 h / 20 °C / Inert atmosphere

With pyridine; N-iodo-succinimide; sodium hydride; N,N-dimethyl-aniline; trichlorophosphate; In dichloromethane; acetonitrile; mineral oil;
DOI:10.1002/ejoc.201300261