(2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Base Information

Chemical Name:(2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester
CAS No.:1026656-91-6
Molecular Formula:C₁₆H₂₂N₄O₄
Molecular Weight:334.375
Hs Code.:

Synonyms:(2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Suppliers and Price of (2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

There total 10 articles about (2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 654666-10-1
(2S,4R)-4-(N,N'-di-tert-butoxycarbonyl-2-guanidinoethyl)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid tert-butyl ester

: 1026656-91-6
(2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 10h;
DOI:10.1021/jm030232j

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1026656-91-6
(2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: aq. NaOH / 20 h / 20 °C

2: 6.0 g / 6 h / 80 °C

3: 84 percent / PDC; MS 4A / CH₂Cl₂ / 2 h / 20 °C

4: 98 percent / LiAlH(OtBu)3 / tetrahydrofuran / 2 h / -78 °C

5: cyanomethylenetributylphosphorane / toluene / 20 h / 100 °C

6: Mg; HgCl₂ / methanol; tetrahydrofuran / 2 h / 20 °C

7: CoCl₂*H₂O; NaBH₄ / methanol / 2 h / -20 °C

8: tetrahydrofuran / 12 h / 20 °C

9: TFA / CH₂Cl₂ / 10 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; dipyridinium dichromate; magnesium; lithium tri-t-butoxyaluminum hydride; cyanomethylenetributyl-phosphorane; trifluoroacetic acid; cobalt(II) chloride; mercury dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 5: Mitsunobu type reaction;
DOI:10.1021/jm030232j

Reference yield:

: 224321-05-5
(2S,4S)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid tert-butyl ester

: 1026656-91-6
(2S,4R)-4-(2-Guanidino-ethyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: cyanomethylenetributylphosphorane / toluene / 20 h / 100 °C

2: Mg; HgCl₂ / methanol; tetrahydrofuran / 2 h / 20 °C

3: CoCl₂*H₂O; NaBH₄ / methanol / 2 h / -20 °C

4: tetrahydrofuran / 12 h / 20 °C

5: TFA / CH₂Cl₂ / 10 h / 0 °C

With sodium tetrahydroborate; magnesium; cyanomethylenetributyl-phosphorane; trifluoroacetic acid; cobalt(II) chloride; mercury dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Mitsunobu type reaction;
DOI:10.1021/jm030232j