Technology Process of Toluene-4-sulfonic acid (2R,3S)-3-hydroxy-2-methyl-3,4-diphenyl-butyl ester
There total 4 articles about Toluene-4-sulfonic acid (2R,3S)-3-hydroxy-2-methyl-3,4-diphenyl-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / LAH / diethyl ether / 3 h / Ambient temperature
2: Ti(O-i-Pr)4, D-(-)-diethyl tartrate, tert-butyl hydroperoxide (TBHP) / CH2Cl2 / 5 h / -20 °C
3: 94 percent / LAH / diethyl ether / 3.5 h / Ambient temperature
4: 73 percent / pyridine / 22 h / 0 °C
With
pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; diethyl (2S,3S)-tartrate;
In
diethyl ether; dichloromethane;
DOI:10.1021/jo00356a034
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Ti(O-i-Pr)4, D-(-)-diethyl tartrate, tert-butyl hydroperoxide (TBHP) / CH2Cl2 / 5 h / -20 °C
2: 94 percent / LAH / diethyl ether / 3.5 h / Ambient temperature
3: 73 percent / pyridine / 22 h / 0 °C
With
pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; lithium aluminium tetrahydride; diethyl (2S,3S)-tartrate;
In
diethyl ether; dichloromethane;
DOI:10.1021/jo00356a034
