Technology Process of (R)-3-(3-(benzyloxy)propyl)morpholine
There total 3 articles about (R)-3-(3-(benzyloxy)propyl)morpholine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-((5-(benzyloxy)pent-2-yn-1-yl)oxy)ethanamine;
With
C42H58N4O2Ti;
In
toluene;
at 110 ℃;
for 14h;
Inert atmosphere;
Schlenk technique;
With
formic acid; [{(1S,2S-N-p-toluenesulfonyl-1,2-diphenylethanediamine)}(η6-p-cymene)RuCl]; triethylamine;
In
N,N-dimethyl-formamide; toluene;
at 20 ℃;
for 14h;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201206826
- Guidance literature:
-
With
[(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; triethylamine;
In
N,N-dimethyl-formamide;
at 23 ℃;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.joc.6b01884
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetra-(n-butyl)ammonium iodide; sodium iodide; potassium hydroxide / tetrahydrofuran / 24 h / Reflux
2: methanol / 0 - 23 °C
3: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube
4: formic acid; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 23 °C / Inert atmosphere; Schlenk technique
With
[(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV); tetra-(n-butyl)ammonium iodide; triethylamine; sodium iodide; potassium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
1: |Williamson Ether Synthesis;
DOI:10.1021/acs.joc.6b01884
