2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]acetic Acid

Base Information

• Chemical Name: 2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]acetic Acid
• CAS No.: 16422-05-2
• Molecular Formula: C₇H₁₃N₃O₄
• Molecular Weight: 203.198
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID30427403
• Nikkaji Number: J653.924F
• Metabolomics Workbench ID: 81863
• Mol file: 16422-05-2.mol

Synonyms:H-Gly-Ala-Gly-OH;16422-05-2;glycylalanylglycine;Gly-Ala-Gly;2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]acetic Acid;Glycyl-L-alanylglycine;(S)-2-(2-(2-Aminoacetamido)propanamido)acetic acid;Gly-Ala-Gly-OH;Glycyl-alanyl-glycine;Glycyl-L-alanyl-glycine;SCHEMBL11656504;DTXSID30427403;CHEBI:163420;UGVQELHRNUDMAA-BYPYZUCNSA-N;HY-P4230;MFCD00083689;AKOS022181526;CS-0653232;2-[(2S)-2-(2-aminoacetamido)propanamido]acetic acid;2-[[(2S)-2-[(2-azaniumylacetyl)amino]propanoyl]amino]acetate

Chemical Property of 2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]acetic Acid

Chemical Property:

• Vapor Pressure: 3.53E-16mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 604.6°C at 760 mmHg
• Flash Point: 319.5°C
• PSA: 121.52000
• Density: 1.314g/cm³
• LogP: -0.86730
• Storage Temp.: -15°C
• XLogP3: -4.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 203.09060590
• Heavy Atom Count: 14
• Complexity: 241

Purity/Quality:

99%+, ^*data from raw suppliers

H-Gly-Ala-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)NCC(=O)O)NC(=O)CN
• Isomeric SMILES: C[C@@H](C(=O)NCC(=O)O)NC(=O)CN

Technology Process of 2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]acetic Acid

There total 5 articles about 2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-carbobenzoxyglycyl-L-alanylglycine benzyl ester (7801-73-2) → Gly-Ala-Gly (16422-05-2,53298-65-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; acetone;

DOI:10.1007/BF00650418

Reference yield:

→ Gly-Ala-Gly (16422-05-2,53298-65-0)

Guidance literature:

With palladium; acetic acid; Hydrogenation;

DOI:10.1021/ja01151a513

Reference yield:

(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionic acid (3079-63-8) → Gly-Ala-Gly (16422-05-2,53298-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / N,N'-dicyclohexylcarbodiimide

2: 90 percent / H₂ / Pd/C / acetone; H₂O

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetone;

DOI:10.1007/BF00650418

upstream raw materials:

N-carbobenzoxyglycyl-L-alanylglycine benzyl ester

(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionic acid

Refernces

• 1、 Schwederski, Brigitte E.,Margerum, Dale W.. "Effect of hydroxide ion on the kinetics of triethylenetetramine displacement of tripeptides from copper(II) complexes". . p. 3472 - 3476. Retrieved 2008/10/08.