O-Desmethyl Tramadol Hydrochloride

Base Information

Chemical Name:O-Desmethyl Tramadol Hydrochloride
CAS No.:16412-54-7
Molecular Formula:C15H23NO2.ClH
Molecular Weight:285.814
Hs Code.:2922509090
UNII:XL5VDC061E
Wikidata:Q27293887
Mol file:16412-54-7.mol

Synonyms:O-demethyl tramadol;O-demethyltramadol;O-demethyltramadol hydrochloride;O-desmethyltramadol;tramadol M1 metabolite

Suppliers and Price of O-Desmethyl Tramadol Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
racO-DesmethylTramadolHCl
2.5 mg
$ 890.00

American Custom Chemicals Corporation
O-DESMETHYL TRAMADOL HYDROCHLORIDE 95.00%
5MG
$ 500.06

Total 48 raw suppliers

Chemical Property of O-Desmethyl Tramadol Hydrochloride

Chemical Property:

Appearance/Colour:White solid
Vapor Pressure:3.37E-08mmHg at 25°C
Melting Point:219-221 °C
Boiling Point:431.1 °C at 760 mmHg
Flash Point:214.5 °C
PSA：43.70000
LogP:3.13360
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:285.1495567
Heavy Atom Count:19
Complexity:269

Purity/Quality:

99% ^*data from raw suppliers

racO-DesmethylTramadolHCl ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CC1CCCCC1(C2=CC(=CC=C2)O)O.Cl
Isomeric SMILES:CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)O)O.Cl
Uses A metabolite of Tramadol, an analgesic

Technology Process of O-Desmethyl Tramadol Hydrochloride

There total 2 articles about O-Desmethyl Tramadol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 73986-53-5,80456-81-1,144830-14-8,144830-15-9
(±)-cis-2-[(dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol

: 16412-54-7,185453-02-5
(+/-)-mono-O-demethyltramadol hydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 25 ℃; Cooling with ice;

Reference yield:

: 36282-47-0,22204-88-2
tramadol hydrochloride

: 16412-54-7,185453-02-5
(+/-)-mono-O-demethyltramadol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 0.25 h / 20 °C

2: diisobutylaluminium hydride / toluene / 23 h / Cooling with ice; Inert atmosphere; Reflux

3: hydrogenchloride / isopropyl alcohol / 25 °C / Cooling with ice

With hydrogenchloride; diisobutylaluminium hydride; sodium hydroxide; In water; isopropyl alcohol; toluene;