(1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol

Base Information

• Chemical Name: (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol
• CAS No.: 222022-88-0
• Molecular Formula: C₁₆H₂₄O₂
• Molecular Weight: 248.365
• Mol file: 222022-88-0.mol

Synonyms:(1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol

Chemical Property of (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol

There total 19 articles about (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1'S)-3-benzyloxy-4-methoxy-5-(1',2',2'-trimethylcyclopentyl)toluene (222022-95-9) → (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol (222022-88-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(98)02487-3

Reference yield:

(S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol (86996-95-4) → (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol (222022-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / acetone / 48 h

2: 98 percent / Cs₂CO₃ / acetone / 48 h

3: H₂ / Pd/C / diethyl ether; ethyl acetate / 5 h / atmospheric pressure

With hydrogen; potassium carbonate; caesium carbonate; palladium on activated charcoal; In diethyl ether; ethyl acetate; acetone;

DOI:10.1021/ja001455r

Reference yield:

(1'S)-2-benzyloxy-4-methyl-6-(1',2',2'-trimethylcyclopentyl)phenol (222022-94-8) → (1'S)-2-methoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)phenol (222022-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / Cs₂CO₃ / acetone / 48 h

2: H₂ / Pd/C / diethyl ether; ethyl acetate / 5 h / atmospheric pressure

With hydrogen; caesium carbonate; palladium on activated charcoal; In diethyl ether; ethyl acetate; acetone;

DOI:10.1021/ja001455r

upstream raw materials:

(1'S)-3-benzyloxy-4-methoxy-5-(1',2',2'-trimethylcyclopentyl)toluene

(1R,2R)-2-(2',3'-dimethoxy-5'-methylphenyl)-1,2-dimethylcyclopentyl-1-carbaldehyde

(1R,2S)-2-(2',3'-dimethoxy-5'-methylphenyl)-1,2-dimethylcyclopentylmethyl alcohol

4-hydroxy-3-iodo-5-methoxybenzyl alcohol

Downstream raw materials:

3,3'-Dimethoxy-6,6'-dimethyl-4,4'-bis-((S)-1,2,2-trimethyl-cyclopentyl)-biphenyl-2,2'-diol

(1''S,1'''S)-[2'-methoxy-5'-methyl-3'-(1''',2''',2'''-trimethylcyclopentyl)-phenyl] 2-bromo-3,4-dimethoxy-5-(1'',2'',2''-trimethylcyclopentyl)benzoate

(1''S,1'''S)-[2'-methoxy-5'-methyl-3'-(1''',2''',2'''-trimethylcyclopentyl)-phenyl] 2-bromo-5-(1'',2'',2''-trimethylcyclopentyl)-3,4-(diphenylmethylidenedioxy)benzoate

(-)-mastigophorene B