Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine
• CAS No.: 110522-54-8
• Molecular Formula: C₆H₁₅N*C₅₄H₅₄N₆O₁₀P₂S₂
• Molecular Weight: 1174.33

Synonyms:Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Chemical Property of Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

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Technology Process of Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

There total 3 articles about Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Dithiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (110522-52-6) + triethylamine (121-44-8) → Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine (110522-54-8)

Guidance literature:

With pyridine; H₂O₂P*C₅H₅N; at 40 ℃; for 1h;

DOI:10.1246/cl.1987.117

Reference yield:

cyclohexylammonium S-phenyl phosphoranilidodithioate (89387-95-1) → Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine (110522-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / mesitylenedisulfonyl chloride, pyridine / 17 h

2: 100 percent / 4M pyridinium phosphinate, pyridine / 1 h / 40 °C

With pyridine; H₂O₂P*C₅H₅N; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride;

DOI:10.1246/cl.1987.117

Reference yield:

S,S-diphenyl 2'-O-(tetrahydropyran-2-yl)-N6-(4,4'-dimethoxytrityl)adenosine-3'-phosphorodithioate (90335-50-5) → Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine (110522-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / mesitylenedisulfonyl chloride, pyridine / 17 h

2: 100 percent / 4M pyridinium phosphinate, pyridine / 1 h / 40 °C

With pyridine; H₂O₂P*C₅H₅N; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride;

DOI:10.1246/cl.1987.117

upstream raw materials:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-2-(phenylamino-phenylsulfanyl-phosphoryloxymethyl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

triethylamine

cyclohexylammonium S-phenyl phosphoranilidodithioate

S,S-diphenyl 2'-O-(tetrahydropyran-2-yl)-N⁶-(4,4'-dimethoxytrityl)adenosine-3'-phosphorodithioate

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