N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

Base Information

Chemical Name:N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene
CAS No.:888030-02-2
Molecular Formula:C₂₄H₂₈N₂O₆S
Molecular Weight:472.562
Hs Code.:

N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9<sup>(10)</sup>-ene

Synonyms:N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

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Chemical Property of N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

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Technology Process of N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

There total 14 articles about N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 888030-10-2
N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

: 888030-02-2
N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 12h;
DOI:10.1021/ol060455e

Reference yield:

: 4-(2-hydroxy-ethyl)-4-methoxy-cyclohexanone

: 888030-02-2
N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.12 g / imidazole / dimethylformamide / 15 h / 20 °C

2.1: 98 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 20 °C

3.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

3.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

3.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

4.1: 90 percent / 0.33 h / 165 °C

5.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

With 1H-imidazole; pinacol borane; potassium hexamethylsilazane; triethylamine; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3.2: Suzuki-Miyaura reaction / 5.1: Mitsunobu reaction;
DOI:10.1021/ol060455e

Reference yield:

: 888030-06-6
2-(2-iodo-5-methoxyphenyl)acetamide

: 888030-02-2
N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹⁰⁾-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃*THF / tetrahydrofuran / 3 h / Heating

1.2: 5.93 g / triethylamine / CH₂Cl₂ / 19 h / 20 °C

2.1: 98 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

3.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

3.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

3.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

4.1: 90 percent / 0.33 h / 165 °C

5.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

With dmap; borane-THF; Pinacolborane; triethylamine; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; dichloromethane; toluene; 3.2: Suzuki-Miyaura reaction / 5.1: Mitsunobu reaction;
DOI:10.1021/ol060455e