(1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

Base Information

Chemical Name:(1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one
CAS No.:122334-27-4
Molecular Formula:C₃₁H₄₁O₄P
Molecular Weight:508.638
Hs Code.:

Synonyms:(1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

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Chemical Property of (1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

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Technology Process of (1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

There total 9 articles about (1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122334-21-8
(1RS,1'RS,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one

: 122334-27-4
(1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

: 122334-28-5
(1R,3aS,4R,7aR)-4-[1,3]Dioxan-2-ylmethyl-1-[(R)-3-(diphenyl-phosphinoyl)-1-methyl-propyl]-7a-methyl-octahydro-inden-5-one

Guidance literature:: With pyridine; hydrogen; palladium on activated charcoal; In ethanol; for 22h; under 42406.1 Torr; Title compound not separated from byproducts;
DOI:10.1021/jo00282a038

Reference yield:

: 17668-60-9
trans-crotyldiphenylphosphine oxide

: 122334-27-4
(1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -60 deg C, 10 min, 2.) -20 deg C to -15 deg C, 5 min

2: H₂, pyridine / 10percent Pd/C / ethyl acetate / 22 h / 1965.2 Torr

3: 2percent potassium hydroxide / methanol / 2 h / Heating

4: 1.) H₂, pyridine, 2.) sodium methoxide / 1.) 10percent Pd/C / 1.) ethanol, 820 psi, 22 h, 2.) methanol, reflux, 2 h

With pyridine; potassium hydroxide; n-butyllithium; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1021/jo00282a038

Reference yield:

: 1120-73-6
2-methyl-2-cyclopenten-1-one

: 122334-27-4
(1RS,1'RS,3aSR,4SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyloctahydro-5H-inden-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -60 deg C, 10 min, 2.) -20 deg C to -15 deg C, 5 min

2: H₂, pyridine / 10percent Pd/C / ethyl acetate / 22 h / 1965.2 Torr

3: 2percent potassium hydroxide / methanol / 2 h / Heating

4: 1.) H₂, pyridine, 2.) sodium methoxide / 1.) 10percent Pd/C / 1.) ethanol, 820 psi, 22 h, 2.) methanol, reflux, 2 h

With pyridine; potassium hydroxide; n-butyllithium; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1021/jo00282a038