2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

Base Information

Chemical Name:2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one
CAS No.:437614-55-6
Molecular Formula:C₃₃H₃₃N₅O₅
Molecular Weight:579.656
Hs Code.:

2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3<i>H</i>-imidazol-4-yl]-3<i>H</i>-pyrimidin-4-one

Synonyms:2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

There total 12 articles about 2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 374081-69-3
5-amino-3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-one

: 437614-55-6
2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

Guidance literature:: nickel; In methanol; for 18h; Heating;
DOI:10.1021/jo0255476

Reference yield:

: 374081-58-0
1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4,5-dibromo-1H-imidazole

: 437614-55-6
2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: ethylmagnesium bromide / diethyl ether / 23 h / 20 °C

2: hydroxylamine hydrochloride; NaHCO₃ / ethanol; H₂O / 2 h / 20 °C

3: 90 percent / acetic anhydride / 3 h / Heating

4: K₂CO₃ / dimethylformamide / 55 °C

5: 88 percent / EtONa / ethanol / 4 h / Heating

6: 90 percent / Raney Ni / methanol / 18 h / Heating

With ethylmagnesium bromide; hydroxylamine hydrochloride; sodium ethanolate; acetic anhydride; sodium hydrogencarbonate; potassium carbonate; nickel; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0255476

Reference yield:

: 374081-60-4
3-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-5-bromo-3H-imidazole-4-carbaldehyde oxime

: 437614-55-6
2-amino-6-[3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / acetic anhydride / 3 h / Heating

2: K₂CO₃ / dimethylformamide / 55 °C

3: 88 percent / EtONa / ethanol / 4 h / Heating

4: 90 percent / Raney Ni / methanol / 18 h / Heating

With sodium ethanolate; acetic anhydride; potassium carbonate; nickel; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo0255476