(1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

Base Information

Chemical Name:(1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane
CAS No.:358395-66-1
Molecular Formula:C₃₁H₃₆O₇
Molecular Weight:520.623
Hs Code.:

Synonyms:(1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

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Chemical Property of (1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

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Technology Process of (1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

There total 13 articles about (1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3450-65-5
diethyl (2-oxoheptyl)phosphonate

: 358395-65-0
(1R,2R,3S,4S)-1,4-di(benzoyloxy)-2-formyl-3-(2-methoxycarbonylethyl)cyclopentane

: 358395-66-1
(1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0040-4039(01)00754-7

Reference yield:

: 3450-65-5
diethyl (2-oxoheptyl)phosphonate

: 358395-65-0
(1R,2R,3S,4S)-1,4-di(benzoyloxy)-2-formyl-3-(2-methoxycarbonylethyl)cyclopentane

: 358395-66-1
(1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

: (1S,2S)-1-(benzoyloxy)-2-(2-methoxycarbonylethyl)-3-(3-oxooct-1(E)-enyl)cyclopent-3-ene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;
DOI:10.1016/S0040-4020(03)00258-8

Reference yield:

: tert-Butyl-[(R)-2-((3aS,5R,6aS)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-iodo-ethoxy]-diphenyl-silane

: 358395-66-1
(1R,2R,3S,4S)-1,4-di(benzoyloxy)-3-(2-methoxycarbonylethyl)-2-((E)-3-oxooct-1-enyl)cyclopentane

Guidance literature:: Multi-step reaction with 10 steps

1: 71 percent / ZnCl₂ / 0.5 h / -20 °C

2: 88 percent / pyridine / 20 °C

3: 100 percent / HgO; HgCl₂ / acetone; H₂O / Heating

4: 74 percent / KHMDS / tetrahydrofuran / 1 h / -80 - 20 °C

5: Jones reagent / acetone / 2 h / -10 - 20 °C

6: 401 mg / diethyl ether

7: 72 percent / Bu₃SnH; BEt₃; O₂ / p-xylene / 0.67 h / 20 °C

8: 68 percent / HCl / diethyl ether; methanol / 20 h / 20 °C

9: Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.5 h / 20 °C

10: 84 mg / NaH / tetrahydrofuran / 0.17 h / 20 °C

With hydrogenchloride; jones reagent; triethyl borane; oxygen; tri-n-butyl-tin hydride; potassium hexamethylsilazane; sodium hydride; Dess-Martin periodane; mercury dichloride; mercury(II) oxide; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; para-xylene; water; acetone; 9: Dess-Martin oxidation;
DOI:10.1016/S0040-4020(03)00258-8