Chlorthalidone Impurity G

Base Information

• Chemical Name: Chlorthalidone Impurity G
• CAS No.: 16289-13-7
• Molecular Formula: C₁₄H₉Cl₂NO₂
• Molecular Weight: 294.137
• Hs Code.: 2933790090
• Mol file: 16289-13-7.mol

Synonyms:Phthalimidine,3-(3,4-dichlorophenyl)-3-hydroxy- (7CI,8CI)

Chemical Property of Chlorthalidone Impurity G

Chemical Property:

• Melting Point: 197-2010C
• Refractive Index: 1.674
• PSA: 52.82000
• LogP: 2.94060
• Storage Temp.: -20?C Freezer
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

ChloroChlorthalidone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.
• Uses: Chlorthalidone impurity. Antihypertensive agent Chlorthalidone impurity. Antihypertensive agent.

Technology Process of Chlorthalidone Impurity G

There total 1 articles about Chlorthalidone Impurity G which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-(3,4-Dicloro-fenil)-3-ossi-ftalimidina (16289-13-7)

Guidance literature:

2-(3,4-Dichlor-benzoyl)-benzoesaeure, 1) Oxalylchlorid, Bzl., Siedetemp., 2) 28percentig. NH3-Lsg., A.;

DOI:10.1021/jm00334a012

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