2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

Base Information

Chemical Name:2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide
CAS No.:345897-60-1
Molecular Formula:C₁₂H₁₄ClNO₄S₂
Molecular Weight:335.832
Hs Code.:

Synonyms:2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

Chemical Property:

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Technology Process of 2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

There total 3 articles about 2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 345897-47-4
SO₂CHClC₄H₆BrNO₂SCH₂

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 2-chloromethanesulfonyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

: 345897-60-1
2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In benzene; for 3h; Heating;
DOI:10.1021/jo010216z

Reference yield:

: 345897-44-1
C-bromo-N-but-3-ynyl-methanesulfonamide

: 345897-60-1
2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 33 percent / DMAP; DIPEA / CH₂Cl₂ / 1.5 h / 0 °C

2: 59 percent / AIBN; (Me₃Si)3SiH / benzene / 3 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene;
DOI:10.1021/jo010216z

Reference yield:

: 345897-41-8
C₉H₁₄BrNO₄SCH₂

: 345897-60-1
2-chloromethanesulfonyl-5-phenyl-2,3,4,7-tetrahydro-[1,2]thiazepine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / TFA / CH₂Cl₂ / 10 h / Heating

2: 33 percent / DMAP; DIPEA / CH₂Cl₂ / 1.5 h / 0 °C

3: 59 percent / AIBN; (Me₃Si)3SiH / benzene / 3 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; benzene;
DOI:10.1021/jo010216z