N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide
CAS No.:1298084-19-1
Molecular Formula:C₃₀H₂₆N₆O₃
Molecular Weight:518.575
Hs Code.:

Synonyms:N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Suppliers and Price of N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

There total 7 articles about N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1298083-94-9
1-(3-(1-(6-aminopyrimidin-4-)-1H-indol-6-yl)phenyl)-3-(2-methoxyphenyl)urea

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1298084-19-1
N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Guidance literature:: With pyridine; at 20 - 50 ℃; for 1.5h;

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 1298084-19-1
N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 13 h / 0 - 20 °C

3: ammonia / isopropyl alcohol; DMSOI (dimethylsulfoxide) / 15 h / 100 °C / In a sealed reactor

4: hydrogen / Raney nickel / 1,4-dioxane; methanol / 1.5 h / 760.05 Torr

5: tetrahydrofuran / 15 h / 20 °C

6: pyridine / 1.5 h / 20 - 50 °C

With pyridine; ammonia; hydrogen; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; DMSOI (dimethylsulfoxide); water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 52415-29-9
6-bromo-1H-indole

: 1298084-19-1
N-(6-(6-(3-(3-(2-methoxyphenyl)ureido)phenyl)-1H-indol-1-yl)pyrimidin-4-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 13 h / 0 - 20 °C

3: ammonia / isopropyl alcohol; DMSOI (dimethylsulfoxide) / 15 h / 100 °C / In a sealed reactor

4: hydrogen / Raney nickel / 1,4-dioxane; methanol / 1.5 h / 760.05 Torr

5: tetrahydrofuran / 15 h / 20 °C

6: pyridine / 1.5 h / 20 - 50 °C

With pyridine; ammonia; hydrogen; sodium hydride; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; DMSOI (dimethylsulfoxide); water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;