4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1252858-53-9
Molecular Formula:C₁₈H₂₀N₄O₄
Molecular Weight:356.381
Hs Code.:

Synonyms:4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Suppliers and Price of 4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

There total 5 articles about 4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 847551-49-9
5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 98-80-6
phenylboronic acid

: 1252858-53-9
4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.07.003

Reference yield:

: 123148-78-7
4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

: 1252858-53-9
4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl acetamide / 0 - 20 °C

1.2: 8 h / 50 °C

2.1: ammonia / methanol / 16 h / 110 °C / Autoclave

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; mineral oil; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1080/15257770.2012.707344

Reference yield:

: C₂₀H₂₂O₄

: 1252858-53-9
4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl acetamide / 0 - 20 °C

1.2: 8 h / 50 °C

2.1: ammonia / methanol / 16 h / 110 °C / Autoclave

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; mineral oil; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1080/15257770.2012.707344