methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

Base Information

Chemical Name:methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate
CAS No.:1373550-26-5
Molecular Formula:C₂₃H₂₈N₂O₆
Molecular Weight:428.485
Hs Code.:

Synonyms:methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

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Chemical Property of methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

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Technology Process of methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

There total 2 articles about methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150884-50-7
benzaldehyde N-boc imine

: 1373550-26-5
methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-(4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-2-yl)-C,C,C-trifluoro-methanesulfonamide / dimethyl sulfoxide / 7 h / 20 °C

2: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium perchlorate / water; tert-butyl alcohol

3: methanol; toluene

With N-(4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-2-yl)-C,C,C-trifluoro-methanesulfonamide; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium perchlorate; In methanol; water; dimethyl sulfoxide; toluene; tert-butyl alcohol; 1: Mannich reaction;
DOI:10.1021/ja301120z

Reference yield:

: C₂₂H₂₆N₂O₆

: 18107-18-1
diazomethyl-trimethyl-silane

: 1373550-26-5
methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

Guidance literature:: In methanol; toluene;
DOI:10.1021/ja301120z

Reference yield: 93.0%

: 1373550-26-5
methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate

: 1373550-27-6
methyl (2R,3R)-3-amino-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: methyl (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In dichloromethane; water;
DOI:10.1021/ja301120z