Technology Process of 3-{[(tert-butoxycarbonyl)amino]methyl}-4-phenylbutanoic acid
There total 10 articles about 3-{[(tert-butoxycarbonyl)amino]methyl}-4-phenylbutanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H21NO3;
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
diethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C
3: hydrazine hydrate / ethanol / 3 h / Heating; Reflux
4: sodium hydrogencarbonate / 1,4-dioxane; water / 5 h
5: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tert-butyl alcohol; tetrahydrofuran / 16 h / 0 - 20 °C
6: sodium periodate / water; tetrahydrofuran / 3.5 h / 0 °C
7: pyridinium chlorochromate / dichloromethane / 20 °C / Molecular sieves 3?
8: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
With
sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; water; sodium hydrogencarbonate; hydrazine hydrate; 4-methylmorpholine N-oxide; triphenylphosphine; pyridinium chlorochromate; lithium hydroxide; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; tert-butyl alcohol;
