2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Base Information

• Chemical Name: 2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester
• CAS No.: 1251933-13-7
• Molecular Formula: C₂₀H₂₃ClN₄O₅
• Molecular Weight: 434.879
• Mol file: 1251933-13-7.mol

Synonyms:2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Chemical Property of 2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

There total 1 articles about 2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester (1178896-02-0,1251932-92-9) + 2-amino-1-(morpholin-4-yl)ethanone hydrochloride (24152-96-3) → 2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester (1251933-13-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 2.5h; Microwave irradiation; Sealed vial;

DOI:10.1016/j.bmc.2010.06.101

Reference yield:

2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester (1251933-13-7) → C19H21ClN4O5 (1251933-91-1)

Guidance literature:

2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester; With water; potassium carbonate; In acetonitrile; at 120 ℃; for 0.75h; Microwave irradiation; Sealed vial;

With hydrogenchloride; In water; ethyl acetate; pH=2;

DOI:10.1016/j.bmc.2010.06.101

upstream raw materials:

2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

2-amino-1-(morpholin-4-yl)ethanone hydrochloride

Downstream raw materials:

C₁₉H₂₁ClN₄O₅