1H-Indole-4-ethanamine

Base Information

• Chemical Name: 1H-Indole-4-ethanamine
• CAS No.: 16176-73-1
• Molecular Formula: C10H12N2
• Molecular Weight: 160.219
• Mol file: 16176-73-1.mol

Synonyms:Indole,4-(2-aminoethyl)- (8CI);2-(1H-Indol-4-yl)ethylamine;4-(2-Aminoethyl)indole;

Chemical Property of 1H-Indole-4-ethanamine

Chemical Property:

• Vapor Pressure: 7.51E-05mmHg at 25°C
• Refractive Index: 1.668
• Boiling Point: 342.5 °C at 760 mmHg
• Flash Point: 187.7 °C
• PSA: 41.81000
• Density: 1.157 g/cm³
• LogP: 2.36940

Purity/Quality:

98%min ^*data from raw suppliers

2-(1H-Indol-4-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-4-ethanamine

There total 8 articles about 1H-Indole-4-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(2-nitrovinyl)indole (49839-99-8,851192-48-8) → 2-(1H-indol-4-yl)ethan-1-amine (16176-73-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0960-894X(98)00138-3

Reference yield: 81.0%

4-(2-nitroethenyl)-1H-indole (49839-99-8,851192-48-8) → 2-(1H-indol-4-yl)ethan-1-amine (16176-73-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Heating / reflux;

Reference yield:

4-(2-nitroethyl)-1H-indole (87149-48-2) → 2-(1H-indol-4-yl)ethan-1-amine (16176-73-1)

Guidance literature:

With iron; ammonium chloride; In water; isopropyl alcohol; for 2h; Reflux; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.03.079

upstream raw materials:

4-(cyanomethyl)indole

4-(2-nitrovinyl)indole

4-formyl indole

(1H-indol-4-yl)methanol

Downstream raw materials:

2,6,7,9,10,14b-hexahydroindolo[3',4':3,4,5]azepino[2,1-a]isoquinoline

4-<2-(N,N-di-n-propylamino)ethyl>indole

Refernces

• 1、 Mehndiratta, Samir,Wang, Ruei-Shian,Huang, Han-Li,Su, Chih-Jou,Hsu, Chia-Ming,Wu, Yi-Wen,Pan, Shiow-Lin,Liou, Jing-Ping. "4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in?vitro and in?vivo". . p. 13 - 23. Retrieved 2017/04/11.
• 2、 -. "PROCESS FOR THE PREPARATION OF ROPINIROLE". Page/Page column 4. . Retrieved 2008/06/13.