4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

Base Information

Chemical Name:4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid
CAS No.:1578254-70-2
Molecular Formula:C₂₁H₁₈FN₃O₃
Molecular Weight:379.391
Hs Code.:

Synonyms:4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

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Chemical Property of 4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

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Technology Process of 4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

There total 4 articles about 4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1578253-28-7
7-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1,4-dihydropyrazolo[4,3-b]indole

: 1578254-70-2
4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

Guidance literature:: With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 220 ℃; for 1h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 85862-81-3
1-azido-2-bromo-4-fluorobenzene

: 1578254-70-2
4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / Reflux

2: 1,2-dichloro-benzene / 2 h / 170 °C

3: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h / 220 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene;

Reference yield:

: 1578253-72-1
5-(2-azido-5-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

: 1578254-70-2
4-(7-fluoro-1-(tetrahydro-2H-pyran-2-yl)pyrazolo[4,3-b]indol-4(1H)-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-benzene / 2 h / 170 °C

2: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h / 220 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; 1,2-dichloro-benzene;