Technology Process of (S)-ethyl 5-(benzylamino)-4-methylpent-2-ynoate
There total 4 articles about (S)-ethyl 5-(benzylamino)-4-methylpent-2-ynoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,3,3-triethoxypropyne;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -10 ℃;
for 1h;
Inert atmosphere;
(S)-3-benzyl-5-methyl-1,2,3-oxathiazolidine 2,2-dioxide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane;
at -10 ℃;
regioselective reaction;
DOI:10.1016/j.tet.2012.09.081
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Cooling with ice; Reflux
3.1: 1H-imidazole; thionyl chloride; triethylamine / dichloromethane / Cooling with ice
3.2: 0 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere
4.2: -10 °C
With
1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2012.09.081
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1H-imidazole; thionyl chloride; triethylamine / dichloromethane / Cooling with ice
1.2: 0 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere
2.2: -10 °C
With
1H-imidazole; n-butyllithium; thionyl chloride; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2012.09.081
